Àäðåñ ýòîé ñòàòüè â èíòåðíåòå: www.biophys.ru/archive/congress2012/proc-p226.htm

 

 

 

ËÀÇÅÐÍÛÅ ÁÈÎÌÅÄÈÖÈÍÑÊÈÅ ÒÅÕÍÎËÎÃÈÈ ÍÀ ÎÑÍÎÂÅ ÑÂÅÒÎÊÈÑËÎÐÎÄÍÎÃÎ ÝÔÔÅÊÒÀ

 

Èâàíîâ À.Â., Çàõàðîâ Ñ.Ä. 1

 

ÔÃÁÓ «Ðîññèéñêèé îíêîëîãè÷åñêèé íàó÷íûé öåíòð èì. Í.Í. Áëîõèíà» ÐÀÌÍ, Ìîñêâà;

å-mail: ivavi@yandex.ru

1Ôèçè÷åñêèé èíñòèòóò èì. Ï.Í. Ëåáåäåâà ÐÀÍ, Ìîñêâà; å-mail: stzakhar@sci.lebedev.ru

 

Ñâåòîêèñëîðîäíûé ýôôåêò (ÑÊÝ) – àêòèâèðîâàíèå, à ïðè áîëüøèõ ñâåòîâûõ äîçàõ – ïîâðåæäåíèå áèîñèñòåì â ðåçóëüòàòå ïðÿìîé ôîòîãåíåðàöèè ñèíãëåòíîãî ìîëåêóëÿðíîãî êèñëîðîäà:

3Î2 (3Óg-,v = 0) + hí 1O2 (1g èëè 1Óg+) 1O2 (1g,v = 0) 3Î2 (3Óg-,v = 0) + áèîýôôåêòû.

ÑÊÝ èíèöèèðóåòñÿ ïîãëîùåíèåì ôîòîíîâ â ïîëîñàõ ýëåêòðîííî-êîëåáàòåëüíîãî âîçáóæäåíèÿ ìîëåêóë êèñëîðîäà, ïðèñóòñòâóþùèõ â çíà÷èòåëüíîé êîíöåíòðàöèè â âîäíîé ôàçå áèîñèñòåì.  äîêëàäå ñîîáùàåòñÿ î ïðîâåäåííûõ àâòîðàìè, èõ ñîòðóäíèêàìè è êîëëåãàìè èññëåäîâàíèÿõ, ïîçâîëÿþùèõ îöåíèòü ïåðñïåêòèâû ïðèìåíåíèÿ ÑÊÝ â áèîìåäèöèíñêèõ òåõíîëîãèÿõ.

1.               ÑÊÝ ëåæèò â îñíîâå áîëüøèíñòâà ìåòîäîâ íèçêîýíåðãåòè÷åñêîé ëàçåðíîé òåðàïèè. Âûáîðîì äåéñòâóþùåãî èçëó÷åíèÿ â îäíîé èç ïîëîñ ïîãëîùåíèÿ 3Î2 ìîæíî ïîâûñèòü òåðàïåâòè÷åñêóþ ýôôåêòèâíîñòü ïðîâîäèìîãî ëå÷åíèÿ. Íàèáîëåå ýôôåêòèâíî èçëó÷åíèå 1264 +5 íì.

2.               Ëó÷åâàÿ òåðàïèÿ îíêîëîãè÷åñêèõ çàáîëåâàíèé çà÷àñòóþ ñîïðîâîæäàåòñÿ ðàçâèòèåì îñòðûõ ëó÷åâûõ ðåàêöèé, ÷òî âûíóæäàåò ïðåðûâàòü íà÷àòûé êóðñ íà ïåðèîä èçëå÷åíèÿ ýòèõ ñîñòîÿíèé. Ðàçðàáîòàí è àïðîáèðîâàí ìåòîä ñâåòîêèñëîðîäíîé òåðàïèè ëó÷åâûõ ðåàêöèé è ïîðàæåíèé, â òîì ÷èñëå ãëóáîêîé îðãàííîé ëîêàëèçàöèè, îáëàäàþùèé âûñîêîé êëèíè÷åñêîé ýôôåêòèâíîñòüþ è áåçîïàñíûé äëÿ ïàöèåíòîâ.

3.               Ðåçóëüòàò òðàíñïëàíòàöèè òêàíåé â ñëó÷àå îòñóòñòâèÿ èììóíîëîãè÷åñêîãî êîíôëèêòà çàâèñèò îò ïðîöåññà âàñêóëÿðèçàöèè. Ïîêàçàíà âîçìîæíîñòü èñïîëüçîâàíèÿ ëàçåðíîãî îáëó÷åíèÿ äëÿ ñòèìóëÿöèè àíãèîãåíåçà, óñêîðåíèÿ âàñêóëÿðèçàöèè è óëó÷øåíèÿ ïðèæèâàåìîñòè òêàíåâûõ òðàíñïëàíòàòîâ ó áåñòèìóñíûõ æèâîòíûõ.

4.                ñïèðòîâîì, õëåáîïåêàðíîì è äðóãèõ âèäàõ áðîäèëüíûõ ïðîèçâîäñòâ ýôôåêòèâíîñòü òåõíîëîãè÷åñêîãî ïðîöåññà îïðåäåëÿåòñÿ àêòèâíîñòüþ äðîææåâûõ êëåòîê,  ëàáîðàòîðíûõ óñëîâèÿõ ïðîäåìîíñòðèðîâàíà âîçìîæíîñòü ñâåòîêèñëîðîäíîé àêòèâàöèè àíàýðîáíîé ðåàêöèè áðîæåíèÿ, â ðåçóëüòàòå ÷åãî ïðîöåññ ñóùåñòâåííî óñêîðÿåòñÿ, ïîâûøàåòñÿ ãëóáèíà ïåðåðàáîòêè ñûðüÿ è âûõîä êîíå÷íîãî ïðîäóêòà.

5.               Êëàññè÷åñêîé îòðàñëüþ áèîòåõíîëîãèé ÿâëÿåòñÿ ïðîèçâîäñòâî ìîëî÷íî-êèñëûõ ïðîäóêòîâ. Ïðîèçâîäèòåëüíîñòü ïðîöåññà çàâèñèò îò ñêîðîñòè ðàçìíîæåíèÿ ñïåöèàëüíî êóëüòèâèðóåìûõ áàêòåðèàëüíûõ øòàììîâ. Ïðèìåíåíèå îäíîêðàòíîãî ñâåòîêèñëîðîäíîãî âîçäåéñòâèÿ íà ìîëîêî êîììåð÷åñêîãî êà÷åñòâà â îïðåäåëåííîé ôàçå ïðîöåññà çàêèñàíèÿ ïîçâîëÿåò ñóùåñòâåííî ñòèìóëèðîâàòü ðàçìíîæåíèå ïîëåçíûõ ìîëî÷íî-êèñëûõ áàêòåðèé.

 

 

BIOMEDICAL TECHNOLOGIES ON A BASIS OF THE LIGHT-OXYGEN EFFECT

 

Ivanov A.V., Zakharov S.D.1

 

N.N.Blokhin Russian Ñancer Research Center of RAMS, Moscow;

e-mail: ivavi@yandex.ru

1 P.N.Lebedev Physical Institute of RAS, Moscow;

e-mail: stzakhar@sci.lebedev.ru

 

The light-oxygen action (LOA) is an activation of biosystems, or inhibition with large light doses, in the result of a direct photogeneration of the singlet molecular oxygen:

3Î2 (3Óg-,v = 0) + 1O2 (1g èëè 1Óg+) 1O2 (1g,v = 0) 3Î2 (3Óg-,v = 0) + bioeffects.

LOA is initiated by photon absorption in absorption bands of oxygen molecules presented in aqueous phase of biosystems in considerable concentrations. The report will describe some author’s researches which allow to determine perspectives of application LOA in biomedical technologies.